Developing and Evaluating Outcomes of an Evidence-based Protocol for the Treatment of Osteomyelitis in Stage IV Pressure Ulcers

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Author(s): 
Robert Rennert, BA; Michael Golinko, MD; Alan Yan, MD; Anna Flattau, MD; Marjana Tomic-Canic, PhD; and Harold Brem, MD, FACS

Abstract: Osteomyelitis affects up to 32% of full-thickness pressure ulcers and increases treatment costs and the risk of systemic complications. Current diagnosis and treatment practices are variable. A literature and retrospective chart review, using a wound electronic medical record (WEMR), were conducted to develop an evidence-based protocol of care for treatment of osteomyelitis in pressure ulcers and to evaluate outcomes of care. The seven steps in the protocol of care include: 1) acknowledgment of osteomyelitis risk in patients with Stage IV pressure ulcers, 2) clinical evaluation for local or systemic signs of infection upon initial presentation, 3) radiographic evaluation (magnetic resonance imaging or bone scan), 4) surgical debridement to remove all nonviable tissue and/or scarred and infected bone, 5) obtaining pathology reports from sterile bone biopsy and deep microbial cultures, 6) targeted systemic antimicrobial therapy, and 7) tissue reconstruction following resolution of infection. WEMR data review (177 patients) identified 50 patients with osteomyelitis (prevalence 28%). Of those, 41 underwent 87 bone debridements for osteomyelitis. Eight (20%) patients experienced complications related to treatment. Average time to discharge following debridement was 4.3 ± 5.7 days and 76% of wounds with more than two consecutive WEMR entries showed a decrease in area at their final visit. The outcomes observed are encouraging and the WEMR facilitates implementation and evaluation of the treatment protocol. Ongoing data acquisition will help assess outcomes and refine the current management protocol and should improve diagnosis and care.

     With 1.3 to 3 million cases diagnosed annually in the US,1 and average charges reaching $37,800,2 pressure ulcers present a serious medical problem for hospitalized and/or bed-bound patients. Pressure ulcers have an estimated prevalence as high as 26% among hospitalized patients,3 53% among nursing home patients,4 and 39% among patients with spinal cord injuries.5 Pressure ulcers are associated with underlying physiologic impairments6-8 and can be difficult to heal even when appropriately treated.

     Pressure ulcers increase the length of hospital stay, risk of nosocomial infection, and treatment costs.9 Evidence shows that pressure ulcers are associated with increased mortality rates10 and have been reported as a cause of death in more than 104,000 persons in the US annually.11 Septicemia was an underlying or contributing cause in 39.7% of all pressure ulcer-associated deaths.11

     Stage IV pressure ulcers are particularly morbid.

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