A Prospective, Open-Label Study to Assess the Clinical Performance of a Foam Dressing in the Management of Chronic Wounds
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This study had a number of limitations. The number of patients was small and the descriptions of the wound surface and depth were based on approximations of the examining physicians and/or patients without additional confirmation from other professionals. Exudate amount also was estimated by the physicians; their subjective observations often are presented in percents as opposed to raw data. The observed reduction in the proportion of highly exudating wounds may have been attributed to the absorptive properties of the dressing, observed advancement of wounds along the healing continuum, or the effects of additional (secondary) dressings and concomitant therapies. In the absence of a control group or a larger sample size, the effects of each variable on the outcomes observed cannot be ascertained.
This non-randomized, non-comparative trial involving 57 outpatients with (mostly) nonhealing wounds provides interesting initial evidence about the clinical performance of a foam dressing. Wound state as well as periwound skin improved in the course of the study. These results suggest that the foam dressing is an appropriate choice for treating heavily to moderately exuding chronic wounds.
This study was sponsored by a grant from Paul Hartmann AG, Heidenheim, Germany.
1. Choucair MM, Fivenson DP. Leg ulcer diagnosis and management. Dermatol Clin. 2001;19(4):659–678.
2. Mendez MV, Raffelto JD, Philipps T, Menzoian JO, Park HY. The proliferative capacity of neonatal skin fibroblast is reduced after exposure to venous ulcer wound fluid: a potential mechanism for senescence in venous ulcers. J Vasc Surg. 1999;30(4):734–743.
3. Trengrove NJ, Stacey MC, MacAuley S, et al. Analysis of the acute and chronic wound environments: the role of proteases and their inhibitors. Wound Rep Reg. 1999;7(6):442–452.
4. Thomas S. Assessment and management of wound exudate. J Wound Care. 1997;6(7):327–328.
5. Reddy M, Kohr R, Queen D, Keast D, Sibbald RG. Practical treatment of wound pain and trauma: a patient-centered approach. An overview. Ostomy Wound Manage. 2003;49(suppl 4A):2–15.
6. Hess CT, Kirsner RS. Orchestrating wound healing: assessing and preparing the wound bed. Adv Skin Wound Care. 2003;16(5):246–259.
7. Schultz GS, Sibbald RG, Falanga V, et al. Wound bed preparation: a systematic approach to wound management. Wound Rep Reg. 2003;11(suppl 1):1–28.
8. Seaman S. Dressing selection in chronic wound management. J Am Podiatr Med Assoc. 2002;92(1):24–33.
9. Ziegler K, Gorl R, Ellermann J, et al. Reduced cellular toxicity of a new silver-containing ointment dressing and clinical performance in non-healing wounds. Skin Pharmacol Physiol.2006;19(3):140–146.
10. Smola H, Zoellner P, Kapp H. Atrauman Ag in the treatment of chronic wounds — an application study on 624 patients. Akt Dermatol. 2005;31:561–565.
11. Lohmann M, Thomsen JK, Edmonds ME, et al. Safety and performance of a new non-adhesive foam dressing for the treatment of diabetic foot ulcers. J Wound Care. 2004;13(3):118.
12. Karlsmark T, Hahn TW, Thomsen JK, Gottrup F. Hydrocapillary dressing to manage exudate in venous leg ulcers. Br J Nurs. 2004;13(suppl 6):S29–S35.
13. Thomas S, Banks V, Fear-Price M, et al. A comparison of two dressings in the management of chronic wounds. J Wound Care. 1997;6(8):383–386.
14. Vanscheidt W, Sibbald RG, Eager CA. Comparing a foam composite to a hydrocellular foam dressing in the management of venous leg ulcers: a controlled clinical study. Ostomy Wound Manage. 2005;50(11):42–55.
15. Bolton LL, Monte K, Pirone LA. Moisture and healing: beyond the jargon. Ostomy Wound Manage. 2000;46(suppl 1A):51S–62S.
16. Grinnel F, Ho CH, Wysocki A. Degradation of fibronectin and vitronectin in chronic wound fluid: analysis by cell blotting, immunoblotting, and cell adhesion assays. J Invest Dermatol. 1992;98(4):410–416.
17. Grinnel F, Zhu M. Fibronectin degradation in chronic wounds depends on the relative levels of elastase, alpha1-proteinase inhibitor, and alpha2-macroglobulin. J Invest Dermatol. 1996;106(2):335–341.
18. Ennis WJ, Meneses P. Wound healing at the local level: the stunned wound. Ostomy Wound Manage. 2000;46(suppl 1A):39S–48S.
19. Cutting KF, White RJ. Maceration of the skin and wound bed. Part 1: its nature and causes. J Wound Care. 2002;11(7):275–278.
20. Fenske NA, Lober CWL. Structural and functional changes of normal aging skin. J Am Acad Dermatol. 1986;15(4 pt 1):571–585.
21. Ryan S, Eager C, Sibbald RG. Venous leg ulcer pain. Ostomy Wound Manage. 2003;49(suppl 4A):16–23.
22. King B. A review of research investigating pain and wound care. J Wound Care. 2003;12(6):219–223.
23. Moffatt CJ, Franks PJ, Hollinworth H. Understanding wound pain and trauma: an international perspective. In: European Wound Management Association. Pain at wound dressing changes: a position document. London, UK: Medical Education Partnership;2002:2–7.